… This study investigated the role of cellular antioxidant defense mechanisms in modulating
the neurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (CGNs) from …

… a model for a relatively common polymorphism (C588T) in the 5′-flanking region of the GCLM
gene, … individuals with genetic polymorphisms of GCLM may be particularly at risk for the …

… of mouse cerebellar granule neurons (CGNs) to domoic acid … that neuronal degeneration
observed during domoic acid–… Similarly, domoic acid neurotoxicity in mixed hippocampal cell …

… neurotoxicity and (3) glutathione (GSH) levels modulate the necrotic and apoptotic effects of
DomA. In particular, neurotoxicity of … The results provide another model indicating a role for …

… of studies have investigated the neurotoxic effects of DomA in … concentration of DomA to
upregulate glutathione (GSH) synthesis (… For example, depletion of GSH by chemical or genetic …

… genes identified as specific markers for glial and neuronal cells … neuronal-glia cultures of
primary rat cerebellar granule cells (… In our mixed neuronal-glial cell culture model, the mRNA …

… in DOM toxicity using an in vitro model of neonatal rat microglia [… seizure or any clinical signs
of neurotoxicity, it did induce … Their cloning has revealed the molecular diversity of the gene …

… Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency. Molecular … Glutathione levels modulate domoic acid induced apoptosis in mouse …

… leads to striatal dopaminergic deficiency, and formation of … apoptotic cell death in cerebellar
granule neurons (CGNs) and … PD cellular model, to show the long-term neurotoxic effects of …

… used primary cultures of cerebellar neurons to test whether … cultures to be a very convenient
experimental model to investigate … Domoic acid neurotoxicity was completely prevented by …